Treatment algorithm for moderate to severe ulcerative colitis
نویسندگان
چکیده
منابع مشابه
Etrolizumab in moderate-to-severe ulcerative colitis
www.thelancet.com Vol 384 July 26, 2014 285 In The Lancet, Séverine Vermeire and colleagues report the results of a double-blind, randomised, placebocontrolled phase 2 trial that studied the eff ects of etrolizumab—a humanised monoclonal antibody that selectively binds the β7 subunit of both the α4β7 and αEβ7 integrins—on the induction of remission in patients with moderate-to-severe ulcerative...
متن کاملExogenous alkaline phosphatase for the treatment of patients with moderate to severe ulcerative colitis.
BACKGROUND Increased activity of intestinal alkaline phosphatase (AP) occurs locally in patients with ulcerative colitis (UC), aimed at repairing inflammatory tissue damage. We evaluated the safety and preliminary efficacy of exogenous AP administered to patients with UC in an open-label, first-in-patient exploratory trial, conducted in the Internal Medicine and Gastroenterology hospital depart...
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Ulcerative colitis (UC) is a chronic inflammatory condition associated with rectal bleeding and urgency, tenesmus, and diarrhea. Several medical therapies can be used in the treatment of UC. Aminosalicylates are widely used based on their efficacy in the induction and maintenance of remission. Although corticosteroids are effective in patients with more severe disease, systemic use is associate...
متن کاملDevelopments in the treatment of moderate to severe ulcerative colitis: focus on adalimumab
In selected patients with moderate to severe active ulcerative colitis who have failed to respond or are poorly responsive to standard pharmacologic forms of treatment with corticosteroids and immunosuppressive agents, therapy with a biological agent may be considered. While infliximab is an established tumor necrosis factor blocker and has a longer history of clinical use, adalimumab is an alt...
متن کاملSURGICAL TREATMENT OF ULCERATIVE COLITIS
This is a preliminary report of 28 patients with ulcerative colitis who we surgically treated with "J" pouch endorectal pull-through operation from 1978 to 1996. All patients are continent with a median stool frequency of 4 times per day, no night soilage. low postoperative complications and one mortality due to pulmonary embolism.
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ژورنال
عنوان ژورنال: Swiss Medical Weekly
سال: 2011
ISSN: 1424-7860,1424-3997
DOI: 10.4414/smw.2011.13235